After cracking the case of a lifetime, officers Scmidt (Hill) and Jenko (Tatum) are back on the streets to investigate a villainous drug smuggler, known only as Ghost (Stormare). The investigation however, proves to be unsuccessful and as their Deputy Chief Hardy (Offerman) puts it ever so bluntly, "just go back and do the same s**t you did last time. Then everyone's happy", the pair soon act upon the chief's stern warning, and return to undercover assignments. This time the pair are placed amongst a university, in order to stop a new drug named "WhyPhy" (it's pronounced like Wi-Fi), from going viral.
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